Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue Montorsi, L.*, Pitcher, M. J.*, Zhao, Y., Dionisi, C., Demonti, A., Tull, T. J., Dhami, P., Ellis, R. J., Bishop, C., Sanderson, J. D., Jain, S., D’Cruz, D., Gibbons, D. L., Winkler, T. H., Bemark, M., Ciccarelli, F. D., Spencer, J. – Nature Communications, 2024 (* joint lead author)

Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets – Povoleri G. A. M., Durham L. E., Gray E. H., Lalnunhlimi, S., Kannambath S., Pitcher M. J., Dhami P., Leeuw T., Ryan S. E., Steel K. J. A., Kirkham B. W., Taams L. S. – Cell Reports, 2023

ChAdOx1 nCoV-19 (AZD1222) vaccine elicits monoclonal antibodies with potent cross-neutralizing activity against SARS-CoV-2 viral variants – Seow, J., Graham, C., Hallett, S. R., Lechmere, T., Maguire, T. J. A., Huettner, I., Cox, D., Khan, H., Pickering, S., Roberts, R., Waters, A., Ward, C. C., Mant, C., Pitcher, M. J., Spencer, J., Fox, J., Malim, M. H., Doores K. J. – Cell Reports, 2022

Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood – Siu, J.H.Y., Pitcher, M. J., Tull, T. J., Velounias. R. L., Guesdon, W., Montorsi, L., Mahbubani, K. T., Ellis, R., Dhami, P., Todd, K., Kadolsky, U. D., Kleeman, M., D’Cruz, D. P., Saeb-Parsy, K., Bemark, M., Pettigrew, G. J., Spencer, J. – Science Immunology, 2022

Disrupted Peyer’s patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus – Trevelin, S. C., Pickering, S., Todd, K., Bishop, C., Pitcher, M., Mesa, J.G., Montorsi, L., Spada, F., Petrov, N., Green, A., Shankar-Hari, M., Neil, S. J. D., Spencer J. – Frontiers in Immunology, 2022

A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially resolved tissue phenotyping at single-cell resolution – Bortolomeazzi, M., Montorsi, L., Temelkovski, D., Keddar, M. R., Acha-Sagredo, A., Pitcher, M. J., Basso, G., Laghi, L., Rodriguez-Justo, M., Spencer, J., & Ciccarelli, F. D. – Nature Communications, 2022

Human marginal zone B cell development from early T2 progenitors – Tull, T. J., Pitcher, M. J., Guesdon, W., Siu, J. H., Lebrero-Fernández, C., Zhao, Y., Petrov, N., Heck, S., Ellis, R., Dhami, P., Kadolsky, U. D., Kleeman, M., Kamra, Y., Fear, D. J., John, S., Jassem, W., Groves, R. W., Sanderson, J. D., Robson, M. D., D’Cruz, D., Bemark, M., Spencer, J. – Journal of Experimental Medicine, 2021

Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle – Pitcher, M. J., Bowness, R., Dobson, S., Eftimie, R., Gillespie, S. H. – Journal of Theoretical Biology, 2020

A spatially heterogeneous network-based metapopulation software model applied to the simulation of a pulmonary tuberculosis infection – Pitcher, M. J., Bowness, R., Dobson, S., Gillespie, S. H. – Applied Network Science, 2018

PySlyde: A Lightweight, Open-Source Toolkit for Pathology Preprocessing – Verghese G., Baptista A., Eke C., Rafique H., Li M., Mohamed F., Bhalla A., Ryan L., Pitcher M., Parisini E., Piazzese C., Ing-Simmons L., Grigoriadis A.

Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity – Bemark M., Pitcher M. J., Dionisi C., Spencer J. – Trends In Immunology, 2024

Heritable diversity in the human antigen inexperienced B cell repertoire – Pitcher, M. J., Spencer J. – Molecular Immunology, 2023

How mechanistic in silico simulations can improve understanding of tuberculosis disease and treatment – Pitcher, M. J., Dobson, S. A., Kelsey, T. W., Chaplain, M. J., Sloan, D. J., Gillespie, S. H. & Bowness, R. – International Journal of Tuberculosis and Lung Disease, 2020

Keystone – B Cells: Multifaceted Functions and Dysfunctions – Feb 2025 – Monaco. Poster: Spatial transcriptomics analysis of gut associated lymphoid tissue reveals an immunomodulatory function for double negative 2 B cells

International Congress of Mucosal Immunology – Jul 2024 – Copenhagen. Poster: “Multiplexed analysis of GALT identifies enrichment of DN2 B cells in the sub-epithelial dome“

BSI Congress – Nov 2023 – Belfast. Poster: “Multiplexed analysis of GALT identifies enrichment of DN2 B cells in the sub-epithelial dome“

BSI Congress – Nov 2021 – Edinburgh. Poster: “Microanatomy of the appendix in ulcerative colitis assessed by imaging mass cytometry“

Acid Fast Club – Jun 2019 – University of St Andrews (Hosted by the Acid Fast Club). Presentation: “Network modelling in tuberculosis: Building the virtual patient”

Conference of Infectious Disease Dynamics – Sep 2018 – University of Cumbria (Hosted by London School of Hygiene and Tropical Medicine). Poster: “A spatially heterogeneous network-based metapopulation software model applied to the simulation of a pulmonary tuberculosis infection“

Complex Networks and their Applications Conference – Nov 2017 – Université Lyon 2. Poster: “A Network-Based Metapopulation Model to Simulate a Pulmonary Tuberculosis Infection“

Conference of Infectious Disease Dynamics – Sep 2017 – University of Cumbria (Hosted by London School of Hygiene and Tropical Medicine). Presentation: “Simulating a pulmonary tuberculosis infection using a network-based metapopulation model”

In silico modelling of in-host tuberculosis dynamics: towards building the virtual patient – University of St Andrews – submitted September 2019, accepted March 2020, graduated July 2020.